GlpBio

1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-PC

目录号: GC90829纯度: >90.00%同义词: 1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-Phosphocholine, 1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-Phosphatidylcholine, Porphyrin-lipid, Pyro-PtdCho

一种磷脂-卟啉共轭物

1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-PC
Cas No.: 1287795-07-6
规格价格库存数量操作
1mg¥1,155.00现货
1
5mg¥5,482.00现货
1
10mg¥10,395.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC is a phospholipid-porprin conjugate that is composed of phosphatidylcholine containing palmitic acid at the sn-1 position and the photosensitizer pyropheophorbide a at the sn-2 position.1 Lipid nanoparticles (LNPs) containing 1-palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC and encapsulating FAM-labeled siRNA are dissociated under irradiation with near-infrared light (NIR) in PC3-Luc6 cells. 1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC then enters the endolysosomal membrane and generates reactive oxygen species (ROS), which disrupt the membrane and allow the release of FAM-labeled siRNA into the cytosol. 1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC-stabilized nanoemulsions loaded with the mitotic inhibitor paclitaxel , combined with laser irradiation, reduce tumor growth and increase survival in a KB squamous cell carcinoma mouse xenograft model.2

产品文档 Product Documents

Purity:>90.00%

化学性质Chemical Properties

CAS 号
1287795-07-6
同义词
1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-Phosphocholine, 1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-Phosphatidylcholine, Porphyrin-lipid, Pyro-PtdCho
分子式
C57H82N5O9P
分子量
1012.3 g/mol
溶解性
DMF: 1 mg/mL,DMSO: 1 mg/mL,Ethanol: 1 mg/mL
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol