1-Methylinosine is a methylated purine nucleoside formed during the degradation of tRNA.1 Urinary levels of 1-methylinosine are increased in patients with acute myelomonocytic leukemia or large cell lung carcinoma. Urinary levels are also increased in patients with breast cancer and are associated with a reduced five-year survival rate.2
1.Mitchell, E.P., Evans, L., Schultz, P., et al.Modified nucleosides in human serumJ. Chromatogr.581(1)31-40(1992) 2.Sasco, A.J., Rey, F.A., Reynaud, C., et al.Breast cancer prognostic significance of some modified urinary nucleosidesCancer Lett.108(2)157-162(1996)