Phosphatidic acids (PAs) can be formed by the acylation of lysophosphatidic acids, the phosphorylation of diacylglycerols, or the removal of the choline group from phosphatidylcholine.[1] They have important roles in intracellular and extracellular signaling. [2][3] 1,2-Dimyristoyl-sn-glycero-3-phosphate is a phospholipid containing the long-chain (14:0) myristic acid inserted at the sn-1 and sn-2 positions. It may be useful in evaluating the role of PAs in micelles, liposomes, and artificial membranes.
Reference:
[1]. Athenstaedt, K., and Daum, G. Phosphatidic acid, a key intermediate in lipid metabolism. European Journal of Biochemistry 266, 1-16 (1999).
[2]. English, D. Phosphatidic acid: A lipid messenger involved in intracellular and extracellular signalling. Cellular Signalling 8, 341-347 (1996).
[3]. Gomez-Cambronero, J. New concepts in phospholipase D signaling in inflammation and cancer. ScientificWorldJournal 10, 1356-1369 (2010).
















