Trilaurin (1,2,3-Trilauroyl-rac-glycerol) is an orally active triacylglycerol that inhibits the formation of neoplasms initiated by dimethylbenzanthracene (DMBA) and promoted by croton oil [1]. Trilaurin is produced from an esterification reaction between glycerol and excess lauric acid [2]. Trilaurin is used in cosmetics as a skin conditioning agent and non-aqueous thickener [3]. Trilaurin can be used as a model compound to optimize the parameters of Fourier Transform Infrared Spectroscopy (FTIR) for efficient identification of related compounds[4].
References:
[1] Johnson Jr W. Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate[J]. International Journal of Toxicology, 2001, 20: 61-94.
[2] Nitbani F O, Tjitda P J P, Nitti F, et al. Antimicrobial properties of lauric acid and monolaurin in virgin coconut oil: a review[J]. ChemBioEng Reviews, 2022, 9(5): 442-461.
[3] Fiume M M, Bergfeld W F, Belsito D V, et al. Amended safety assessment of triglycerides as used in cosmetics[J]. International journal of toxicology, 2022, 41(3_suppl): 22-68.
[4] Lee T H, Chang J S, Wang H Y. Current developments in high‐throughput analysis for microalgae cellular contents[J]. Biotechnology journal, 2013, 8(11): 1301-1314.
Trilaurin (1,2,3-Trilauroyl-rac-glycerol)是一种具有口服活性的三酰甘油，可抑制由二甲基苯并蒽(DMBA)引发、巴豆油促进的肿瘤形成[1]。Trilaurin由甘油与过量月桂酸通过酯化反应生成[2]。Trilaurin在化妆品中用作皮肤调理剂和非水性增稠剂[3]。Trilaurin可作为模型化合物，用于优化傅里叶变换红外光谱参数，以高效鉴定相关化合物[4]。