Zolimidine, a derivate of imidazopyridine, is an orally active antiulcer agent. Zolimidine stimulates mucus secretion in intestinal mucosal cells and enhacnes intestinal wall more resistant to ulceration. Zolimidine exhibits gastroprotective effect in duodenal ulcer research[1][2].
Zolimidine (200 mg/kg；口服) 降低由 Indomethacin (5 mg/kg/天，持续 8 天，直肠) 诱导的大鼠肠道溃疡的发生率[2]。Zolimidine (加在饮食中；1% 含量) 可降低豚鼠由角叉菜胶 (加在饮用水中；5% 含量，持续 40 天) 引起的肠溃疡的发生率[2]。
[1]. Belohlavek D, et al. The effect of zolimidine, imidazopyridine-derivate, on the duodenal ulcer healing. Scand J Gastroenterol Suppl. 1979;54:44.
[2]. Carminati GM, et al. Protective action of zolimidine against two different types of experimental intestinal ulcers. Farmaco, Edizione Pratica (1978), 33(2), 68-79.