WU-FA-01, a drogenated derivative of WU-FA-00, is an antibacterial agent that exhibits high levels of antibacterial activity against Gram-positive strains and also has some anti-inflammatory activity[1].
WU-FA-01(0-25 µg/mL, 24 h) 对革兰氏阳性菌具有剂量依赖性的抑制剂作用，而对革兰氏阴性菌株没有抑制作用[1]。
WU-FA-01(2000-8000µg/mL) 对 TPA 诱导的小鼠耳模型水肿具有剂量依赖性的抑制作用，可以有效保护 TPA 诱导的皮肤炎症[1]。
| Animal Model: | TPA-induced skin inflammation in female Kunming mice[1] |
| Dosage: | 2000, 4000 and 8000 µg/mL |
| Administration: | 20 µL of acetone-loaded agent topically applied to the right ear |
| Result: | Significantly reduced TPA-induced ear edema by 48.16%, 113.97% and 137.32%, respectively, at concentrations of 2000, 4000 and 8000 µg/mL. |
[1]. Pan-Pan Wu, et al. The biological evaluation of fusidic acid and its drogenation derivative as antimicrobial and anti-inflammatory agents. Infect Drug Resist. 2018 Oct 24;11:1945-1957.