Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis.
Wu-5 (10 μM; 24, 48, 72 h) selectively induces the death of FLT3-ITD-positive AML cells[1].Wu-5 (1, 2.5, 5 μM; 24, 48 h) induces apoptosis of FLT3-ITD-positive AML cells in a concentration and time-dependent manner[1].Wu-5 (5 μM; 24 h) induces FLT3-ITD degradation by the proteasome pathway[1].
References:
[1]. Miao Yu, et al. Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta Pharmacol Sin. 2021 Apr;42(4):604-612.