Voriconazole-d3 N-oxide is intended for use as an internal standard for the quantification of voriconazole N-oxide by GC- or LC-MS. Voriconazole N-oxide is a major metabolite of the triazole antifungal voriconazole .[1] It is formed via oxidation of voriconazole by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C19.
References:
[1].Hyland, R., Jones, B.C., and Smith, D.A.Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazoleDrug Metab. Dispos.31(5)540-547(2003).