Vidutolimod sodium

目录号: GC73180纯度: >90.00%同义词: CMP-001 sodium
Vidutolimod sodium是一个CpG-A寡脱氧核苷酸。

Vidutolimod sodium
规格价格库存数量操作
1 mg¥864.00现货
1
5 mg¥2,520.00现货
1
10 mg¥4,095.00现货
1

文献被引

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

Vidutolimod sodium is a CpG-A oligodeoxynucleotide. Vidutolimod sodium is a Toll-like receptor 9 (TLR9) agonist, which activates plasmacytoid dendritic cells (pDCs) and triggers interferon alpha (IFNα) release, leading to a cascade of anti-tumor immune effects.

References:
[1]. Ribas A, Medina T, Kirkwood JM, et al. Overcoming PD-1 Blockade Resistance with CpG-A Toll-Like Receptor 9 Agonist Vidutolimod in Patients with Metastatic Melanoma. Cancer Discov. 2021;11(12):2998-3007.
[2]. Sabree SA, Voigt AP, Blackwell SE, et al. Direct and indirect immune effects of CMP-001, a virus-like particle containing a TLR9 agonist. J Immunother Cancer. 2021;9(6):e002484.
[3]. Cheng Y, Lemke-Miltner CD, Wongpattaraworakul W, et al. In situ immunization of a TLR9 agonist virus-like particle enhances anti-PD1 therapy. J Immunother Cancer. 2020;8(2):e000940.
[4]. Negrao MV, Papadimitrakopoulou VA, Price AC, et al. Vidutolimod in Combination With Atezolizumab With and Without Radiation Therapy in PatientsWith Programmed Cell Death Protein 1 or Programmed Death-Ligand 1 Blockade-Resistant Advanced NSCLC.JTO Clin Res Rep. 2022;4(3):100423. Published 2022 Oct 26.

产品文档 Product Documents

Purity:>90.00%

化学性质Chemical Properties

同义词
CMP-001 sodium
分子量
10301.9 g/mol
溶解性
H<sub>2</sub>O : ≥ 100 mg/mL (9.71 mM)
保存条件
-20&#176;C, sealed storage, away from moisture
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至 37°C,然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备 RT,或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol