GlpBio

VH285-PEG4-C4-Cl

目录号: GC67980同义词: HaloPROTAC 3
VH032-PEG5-C6-Cl (HaloPROTAC 2) 由 E3 配体与 16 个原子相连的复合分子，连接子的接头为 Halogen 基团。VH032-PEG5-C6-Cl 包含基于 VH032 的 VHL 配体和基于 alkyl/ether linker。VH285-PEG4-C4-Cl 是一种高效的 GFP-HaloTag7 降解剂，DC50 为 19 nM。VH285-PEG4-C4-Cl 在浓度为 625 nM 时诱导 90% GFP-Halotag 降解。VH285-PEG4-C4-Cl 与 VHL 结合，IC50 为 0.54 μM。
VH285-PEG4-C4-Cl
Cas No.: 1799506-07-2
规格价格库存数量操作
1mg¥952.00现货
1
5mg¥2,380.00现货
1
10mg¥3,850.00现货
1
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产品描述 Description

VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC50 of 0.54 μM[1].

Treatment with 500 nM VH285-PEG4-C4-Cl (HaloPROTAC 3) is able to induce nearly complete knockdown of both HaloTag7-ERK1 and HaloTag7-MEK1[1].

[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

产品文档 Product Documents

Appearance:A jelly

化学性质Chemical Properties

CAS 号
1799506-07-2
同义词
HaloPROTAC 3
分子式
C41H55ClN4O8S
分子量
799.42 g/mol
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol