Velaresol is an oxyhemoglobin (Hb-O2) stabilizer.1 It increases erythrocyte deformability in isolated human blood from a patient with sickle cell disease when used at a concentration of 1.5 mM. Velaresol (3 or 5 mM) inhibits deoxygenation-induced decreases in erythrocyte deformability in isolated human blood from a patient with sickle cell disease. It decreases oxygen tension and increases oxygen saturation of isolated human sickle erythrocytes when used at a concentration of 5 mM.2
1.Kenny, M.W., and Stuart, J.Preservation of deformability (filterability) of sickle cells by BW12C during progressive deoxygenationBr. J. Haematol.55(3)465-471(1983) 2.Gibson, J.S., Khan, A., Speake, P.F., et al.O2 dependence of K+ transport in sickle cells: The effect of different cell populations and the substituted benzaldehyde 12C79FASEB J.15(3)823-832(2001)