Val-Ala-PAB-SN38 TFA is adrug-linker conjugate for ADC, composed ofADC linkerVal-Ala-PAB and SN38 , which is the active metabolite of theTopoisomeraseIinhibitorIrinotecan[1].
References:
[1].Paul Joseph Mark JACKSON, et al. Antibody-drug conjugates. WO2024013724A1. 2023-07-15.
Val-Ala-PAB-SN38 TFA 是一种 ADC 的药物-连接子偶联物 (drug-linker conjugate for ADC)，由ADC linkerVal-Ala-PAB 和 SN38 组成，SN-38是拓扑异构酶 I (TopoisomeraseI) 抑制剂Irinotecan 的活性代谢产物。