GlpBio

Vafidemstat (ORY-2001)

目录号: GC31101纯度: >98.50%同义词: ORY-2001
Vafidemstat (ORY-2001) (ORY-2001) 是一种口服、脑渗透性、双赖氨酸特异性组蛋白去甲基化酶 (LSD1)/MAO-B 抑制剂。
Vafidemstat (ORY-2001)
Cas No.: 1357362-02-7
规格价格库存数量操作
5mg¥2,520.00现货
1
10mg¥3,780.00现货
1
10mM (in 1mL DMSO)¥2,772.00现货
1
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产品描述 Description

Vafidemstat (ORY-2001) is a dual lysine-specific histone demethylase (LSD1)/MAO-B inhibitor.

Vafidemstat (ORY-2001), a dual LSD1/MAO-B inhibitor, is a novel epigenetic agent for the treatment of neurodegenerative diseases. LSD1 is a protein that participates in transcription regulation complexes; its modulation can be used to tweak transcriptional imbalances in neurodegenerative disease and redress neuroinflammation and cognitive deficit[1]. Vafidemstat (ORY-2001) can be used in the treatment of Alzheimer's disease[2].

[1]. ORYZON presents data on the Phase I trial with ORY-2001 at the 13th International Conference on Alzheimer's and Parkinson's diseases [2]. ORYZON Reports Financial Results and Corporate Update for the 1st Half Ended June 30, 2018.

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
1357362-02-7
同义词
ORY-2001
SMILES
NC1=NN=C(O1)CN[C@H]2[C@H](C3=CC=C(OCC4=CC=CC=C4)C=C3)C2
分子式
C19H20N4O2
分子量
336.39 g/mol
溶解性
DMSO : 50 mg/mL (148.64 mM; Need ultrasonic)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol