Uridine-5'-diphosphoglucuronic Acid (sodium salt) is an agonist for the P2Y14 receptor. Uridine-5'-diphosphoglucuronic Acid (sodium salt) is also a precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and certain microorganisms, and acts as an activated form of glucose in nucleotide sugar metabolism, serving as a substrate for glucose transferase.
Rat liver microsomes were incubated with 1 μM supinoxin.The addition of Uridine-5'-diphosphoglucuronic Acid (sodium salt) in the NADPH-containing incubation mixture did not lead to significant metabolic profile differences from the mixture containing only NADPH, indicating the negligible contribution of Uridine-5'-diphosphoglucuronic Acid (sodium salt)-dependent metabolism in the microsomal clearance of supinoxin[1]. Metabolic reactions containing FDU-PB-22 and human liver microsomes (HLMs) were independent of NADPH but not Uridine-5'-diphosphoglucuronic Acid (sodium salt) [2].
References:
[1]. Liu P, Wu S, et,al. Identification of the metabolites of tofacitinib in liver microsomes by liquid chromatography combined with high resolution mass spectrometry. Biomed Chromatogr. 2021 Jun;35(6):e5081. doi: 10.1002/bmc.5081. Epub 2021 Feb 10. PMID: 33522621.
[2]. Jones S, Yarbrough AL, et,al. Enzymatic analysis of glucuronidation of synthetic cannabinoid 1-naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate (FDU-PB-22). Xenobiotica. 2019 Dec;49(12):1388-1395. doi: 10.1080/00498254.2019.1580403. Epub 2019 Mar 20. PMID: 30739533; PMCID: PMC7133092.
Uridine-5'-diphosphoglucuronic Acid（钠盐）是 P2Y14 受体的激动剂。 Uridine-5'-diphosphoglucuronic Acid (sodium salt) 也是动物组织和某些微生物中含葡萄糖的低聚糖、多糖、糖蛋白和糖脂的前体，在核苷酸糖代谢中作为葡萄糖的活化形式，作为葡萄糖转移酶底物。
大鼠肝微粒体与 1 μM supinoxin 一起孵育。在含有 NADPH 的孵育混合物中添加 Uridine-5'-diphosphoglucuronic Acid（钠盐）不会导致与仅含有 NADPH 的混合物的显着代谢特征差异，表明Uridine-5'-二磷酸葡萄糖醛酸（钠盐）依赖性代谢对 supinoxin 微粒体清除的贡献可忽略不计[1]。含有 FDU-PB-22 和人肝微粒体 (HLM) 的代谢反应不依赖于 NADPH，但不依赖于尿苷 5'-二磷酸葡萄糖醛酸（钠盐）[2]。