GlpBio

UR778Br

目录号: GC74047纯度: >99.00%
UR778Br靶向IQGAP1蛋白的GTP酶激活蛋白相关结构域（GRD结构域）。
UR778Br
Cas No.: 866127-80-2
规格价格库存数量操作
5 mg¥810.00现货
1
10 mg¥1,350.00现货
1
25 mg¥2,700.00现货
1
50 mg¥4,320.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

UR778Br targets the GTPase-activating protein-related domain (GRD domain) of IQGAP1 proteins. UR778Br inhibits the proliferation of human acute myeloid leukemia (AML), arrests the cell cycle at the G2/M phase, and induces apoptosis. UR778Br inhibits colony formation of primary and AML cells, without significant impacts on normal bone marrow cells.

References:
[1]. Sahasrabudhe DM, et al., In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia. Sci Rep. 2024 Jun 4;14(1):12868.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
866127-80-2
分子式
C20H20BrNO4
分子量
418.28 g/mol
溶解性
DMSO : 14.29 mg/mL (34.16 mM; ultrasonic and warming and adjust pH to 3 with 1 M HCL and heat to 60°C)
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol