UDP-α-D-Glucose (sodium salt hydrate)

UDP-α-D-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y₁₄ receptor (EC₅₀ = 0.35 μM), an atypical P2Y receptor involved in the activation of dendritic cells and glial cells.¹ It can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.²

1.Jacobson, K.A., Ivanov, A.A., de Castro, S., et al.Development of selective agonists and antagonists of P2Y receptorsPurinergic Signal.5(1)75-89(2009) 2.Lecca, D., Trincavelli, M.L., Gelosa, P., et al.The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repairPLoS One3(10)(2008)