[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a fragments 22-37 of rat calcitonin gene related peptide (CGRP), targeting CGRP receptor and adenylate cyclase. Calcitonin is mainly produced by thyroid C cells while CGRP is secreted and stored in the nervous system.

Calcitonin Gene Related Peptide (CGRP) in humans, exists in two forms: CGRP alpha (α-CGRP or CGRP I), and CGRP beta (β-CGRP or CGRP II)^[2].
[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat shows the receptor binding affinity mainly depending on the carboxyterminal end while the ability to stimulate adenylate cyclase (AC) enzyme mainly depending on the aminoterminal end^[3].

References:
[1]. Jia S, et al. Calcitonin gene-related peptide enhances osteogenic differentiation and recruitment of bone marrow mesenchymal stem cells in rats. Exp Ther Med. 2019 Aug;18(2):1039-1046.
[2]. Russell FA, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014 Oct;94(4):1099-142.
[3]. Heino P, et al. Binding of CGRP analogs and their effect on adenylate cyclase activity in porcine iris-ciliary body. J Ocul Pharmacol Ther. 1998 Dec;14(6):543-54.