Tropinone is a polyketide synthase-derived tropane that has been found in A. belladonna.1,2,3 It is a central intermediate in the biosynthesis of various tropane alkaloids, including (–)-hyoscyamine , (+)-hyoscyamine, scopolamine, atropine , and cocaine.
1.Bedewitz, M.A., Jones, A.D., D'Auria, J.C., et al.Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclizationNat. Commun.9(1)5281(2018) 2.Piechowska, K., Mizerska-Kowalska, M., Zdzisińska, B., et al.Tropinone-derived alkaloids as potent anticancer agents: Synthesis, tyrosinase inhibition, mechanism of action, DFT calculation, and molecular docking studiesInt. J. Mol. Sci.21(23)9050(2020) 3.Majewski, M., and Lazny, R.Synthesis of tropane alkaloids via enantioselective deprotonation of tropinoneJ. Org. Chem.60(18)5825–5830(1995)