Trimethylamine oxide-15N is the deuterium labeledTrimethylamine N-oxide.Trimethylamine N-oxideis a gut microbe-dependent metabolite of dietary choline andothertrimethylamine-containing nutrients.Trimethylamine N-oxideinduces inflammation by activating the ROS/NLRP3 inflammasome.Trimethylamine N-oxidealso accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].
References:
[1].Wei Shuai, et al. High-choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction. J Card Fail. 2020 May 14;S1071-9164(19)31802-0.
Trimethylamine oxide-15N 是Trimethylamine N-oxide 的氘代物。Trimethylamine N-oxide 是一种膳食胆碱和其他含三甲胺营养素的肠道微生物依赖性代谢产物。Trimethylamine N-oxide 通过激活ROS/NLRP3炎性体诱导炎症。Trimethylamine N-oxide 还通过激活TGF-β/smad2信号通路来加速成纤维细胞的分化并诱导心脏纤维化。