Triciribine Phosphate

Triciribine phosphate is an Akt activation inhibitor and an active metabolite of the prodrug triciribine .^1,2 Upon entry into cells, triciribine is metabolized to triciribine phosphate by adenosine kinase (AK).² It binds to the Pleckstrin homology (PH) domain of Akt and prevents its recruitment to the plasma membrane in MDA-MB-468 cells.¹ Triciribine phosphate reduces the proliferation of A1847 and A2780 ovarian cancer cells (IC₅₀s = 1.6 and 18 µM, respectively).³ It inhibits HIV-1 reverse transcriptase activity in CEM-SS cells (IC₅₀ = 0.04 µM), as well as herpes simplex virus 1 (HSV-1) replication in BS-C-1 cells and human cytomegalovirus (CMV) plaque formation in HFF-1 IRR cells (IC₅₀s = 20 and 0.8 µM, respectively).⁴