TP748,an isoxazole, is a key intermediate for fully synthetic tetracyclines.
A robust, cost effective and high yielding manufacturing process for enantiomerically enriched (S)-allylic amine 3, a key intermediate for fully synthetic tetracyclines have been developed[1].
References:
[1]. Wu-Yan Zhang, et al. Process Research and Development of TP-808: A Key Intermediate for the Manufacture of Synthetic Tetracyclines. Process Res. Dev. 2017, 21, 3, 377-386.