Tosufloxacin is a fluoroquinolone antibiotic. It has activity against diverse aerobic and anaerobic bacteria in vitro.1,2 Tosufloxacin is also effective against bacterial persisters, showing significant activity against S. aureus and uropathogenic E. coli persisters.3,4 As with many other quinolones, tosufloxacin use can be associated with significant side effects.5
1.Espinoza, A.M., Chin, N.-X., Novelli, A., et al.Comparative in vitro activity of a new fluorinated 4-quinolone, T-3262 (A-60969)Antimicrob. Agents Chemother.32(5)663-670(1988) 2.Fernandes, P.B., Chu, D.T.W., Swanson, R.N., et al.A-61827 (A-60969), a new fluoronaphthyridine with activity against both aerobic and anaerobic bacteriaAntimicrob. Agents Chemother.32(1)27-32(1988) 3.Niu, H.Y., Cui, P., Yee, R., et al.A clinical drug library screen identifies tosufloxacin as being highly active against Staphylococcus aureus persistersAntibiotics (Basel)4(3)329-336(2015) 4.Niu, H.Y., Cui, P., Shi, W., et al.Identification of Anti-Persister Activity against Uropathogenic Escherichia coli from a Clinical Drug LibraryAntibiotics (Basel)4(2)179-187(2015) 5.Rubinstein, E.History of quinolones and their side effectsChemotherapy47 (Suppl. 3)44-48(2001)