TNC 蛋白是一种细胞外基质蛋白，在发育过程中引导神经元和轴突迁移方面发挥着至关重要的作用，有助于突触可塑性和神经元再生等过程。它促进单层星形胶质细胞上生长的皮层神经元的神经突生长，表明它参与神经系统内复杂的细胞相互作用。作为整合素 α-8/β-1、α-9/β-1、α-V/β-3 和 α-V/β-6 的配体，TNC 建立了细胞通讯和信号传导所必需的分子连接。在肿瘤中，TNC 通过促进内皮细胞的伸长、迁移和萌芽来刺激血管生成。在结构上，TNC 以同源六聚体形式存在，在三卷曲螺旋区域可能形成同源三聚体，并通过两端的二硫环进一步稳定。这种多功能蛋白质还与 CSPG4 相互作用，表明它参与不同生物背景下的多种细胞和分子过程。
TNC Protein, Human (His)
目录号: GC27166纯度: >98%
TNC 蛋白引导神经元和轴突迁移，并有助于发育、突触可塑性和神经元再生。TNC 蛋白, Human (His) 是重组的 TNC 蛋白，由 E. coli 表达，带有 N-6*His 标签。
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 5ug | ¥855.00 | 现货 | 1 | |
| 10ug | ¥1,440.00 | 现货 | 1 | |
| 50ug | ¥6,201.00 | 现货 | 1 |
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文献被引
本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
产品描述 Description
产品文档 Product Documents
Purity:>98%
Product Data
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Source
E. coli
Physical Appearance
Lyophilized powder
Synonyms
TNC 蛋白, Human (His); Cytotactin; Glioma associated extracellular matrix antigen; GMEM; TenascinC
Amino Acid Sequence
DSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA
Apparent Molecular Weight
Approximately 36-39.5 kDa Da
Stability
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Biological Activity
Measured by the ability of the immobilized protein to block Fibronectin-mediated adhesion of NIH-3T3 mouse embryonic fibroblast cells. rhTenascin-C immobilized at 15 μg/mL, in the presence of 0.1 μg/mL human Fibronectin, will block approximately 54.61% NIH3/T3 cell adhesion (5x10<sup>4</sup> cells/well, 100 μL/well)
Formulation
Lyophilized from a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4 or 10 mM Tris-HCI,1 mM EDTA, 6% Trehalose,pH 8.0 or 50 mM Tris-HCI.300 mM NaCl,pH 7.4.