TMX-4153 is a bivalent degrader. TMX-4153 rapidly and selectively degrades endogenous PIP4K2C by recruiting the von Hippel-Lindau (VHL) E3 ligase complex, with a KD value of 42 nM. TMX-4153 can be used to synthesize PROTAC.
TMX-4153 (0.01, 0.05, 0.1, 0.5, 1 µM; 6 h) can selectively degrades PIP4K2C in MOLT4 cells[1].
References:
[1]. Teng M, et al. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angew Chem Int Ed Engl. 2023 Apr 24;62(18):e202302364.