Tirucallol is a triterpenoid that has been found in Camellia and has reverse transcriptase inhibitory and anti-inflammatory activities.1,2 It inhibits HIV-1 reverse transcriptase (IC50 = 3.8 ?M).1 Tirucallol (25, 50, and 100 ?M) reduces nitric oxide (NO) and prostaglandin E2 production in LPS-stimulated isolated mouse peritoneal macrophages.2 Topical application of tirucallol (0.25, 0.5, and 1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate in mice.
1.Akihisa, T., Ogihara, J., Kato, J., et al.Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptaseLipids36(5)507-512(2001) 2.Fernandez-Arche, A., Saenz, M.T., Arroyo, M., et al.Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latexPhytomedicine17(2)146-148(2010)