Thymine-13C5,15N2 is intended for use as an internal standard for the quantification of thymine by GC- or LC-MS. Thymine is a pyrimidine base.[1] It forms complementary base pairs with the purine adenine in DNA.[1] Thymine is produced by the catabolism of thymidine via thymidine phosphorylase.[2] It is replaced with uracil in RNA.[3]
References:
[1].Ghannam, J.Y., Wang, J., and Jan, A.Biochemistry, DNA Structure1-5(2021).
[2].Brown, N.S., and Bicknell, R.Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesisBiochem. J.334(Pt 1)1-8(1998).
[3].Banoub, J.H., Newton, R.P., Esmans, E., et al.Recent developments in mass spectrometry for the characterization of nucleosides, nucleotides, oligonucleotides, and nucleic acidsChem. Rev.105(5)1869-1915(2005).