Thymidine 5 '- diphosphate (dTDP) sodium is a key product in the synthesis of pyrimidine in living organisms. Thymidine 5 '- diphosphate sodium is produced by thymidine kinase (TMPK) catalyzing the phosphorylation of 5' - monophosphate thymidine (dTMP), which requires ATP and Mg2+. Thymidine 5 '- diphosphate sodium is further catalyzed by TMPK to thymidine 5' - triphosphate (dTTP). Detecting the level of Thymidine 5 '- diphosphate sodium can be used to indicate TMPK activity.
Thymidine 5′-diphosphate (dTDP) sodium 是生物体内合成嘧啶的关键产物。Thymidine 5′-diphosphate sodium 由胸苷酸激酶 (TMPK) 催化5'-单磷酸胸苷 (dTMP) 磷酸化而产生，该过程需要 ATP 和 Mg2+。Thymidine 5′-diphosphate sodium 再进一步被 TMPK 催化为胸苷 5'-三磷酸 (dTTP)。检测 Thymidine 5′-diphosphate sodium 水平可以用来指示 TMPK 活性。