Thrombin-sensitive peptide is a synthetic peptide that contains a thrombin-releasable quencher.1 It has been conjugated to an anti-CD41 antibody via click chemistry for use as a platelet-targeting sensor in a microfluidic model of thrombosis and a mouse model of thrombosis to detect increases in fluorescence, which indicate increased thrombin activity.
1.Welsh, J.D., Colace, T.V., Muthard, R.W., et al.Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouseJ. Thromb. Haemost.10(11)2344-2353(2012)