GLPBio

THP1 Lipid

目录号: GC92353纯度: >98.00%同义词: Tetrahydropyrimidine 1 Lipid
THP1 lipid is an ionizable cationic lipid (pKa = 5.451) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.
THP1 Lipid
规格价格库存数量操作
5mg¥1,525.00现货
1
10mg¥2,741.00现货
1
25mg¥6,483.00现货
1
50mg¥11,442.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

THP1 lipid is an ionizable cationic lipid (pKa = 5.451) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing THP1 lipid and encapsulating mRNA encoding luciferase induce luciferase expression in HEK293 and RAW 264.7 cells. LNPs containing THP1 lipid and 1-palmitoyl-2-oleoyl-sn-glycero-3-PE accumulate in mouse liver after intravenous administration and have a higher transfection efficiency than LNPs containing DLin-MC3-DMA . THP1 lipid-containing LNPs encapsulating Cre mRNA induce the expression of tdTomato in the liver of Ai14 mice engineered to express tdTomato upon Cre-mediated recombination.

产品文档 Product Documents

Purity:>98.00%Appearance:A solution in ethanol

化学性质Chemical Properties

同义词
Tetrahydropyrimidine 1 Lipid
化学名
diethyl 1,3-dioctyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate
SMILES
O=C(OCC)C1=C(C(OCC)=O)N(CCCCCCCC)CN(CCCCCCCC)C1
分子式
C26H48N2O4
分子量
452.6704 g/mol
溶解性
Ethanol: Soluble: ≥10 mg/mL
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol