Tetrahydrocoptisine is an alkaloid that has been found in C. impatiens and has anti-inflammatory and antioxidant activities.1,2 It inhibits LPS-induced NF-κB activation and production of nitric oxide (NO), TNF-α, and IL-6 in isolated mouse peritoneal macrophages when used at concentrations ranging from 0.001 to 1 ?g/ml.1 Tetrahydrocoptisine (10 and 30 mg/kg) inhibits xylene-induced ear edema in mice, and it decreases serum levels of TNF-α in a mouse model of LPS-induced septic shock. It reduces the severity of ethanol-induced gastric ulcers in mice when administered at doses of 10 or 20 mg/kg.2
1.Li, W., Huang, H., Zhang, Y., et al.Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-α, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-κB activation and MAPK pathwayEur. J. Pharmacol.715(1-3)62-71(2013) 2.Li, W., Huang, H., Niu, X., et al.Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in miceToxicol. Appl. Pharmacol.272(1)21-29(2013)