Tesofensine is a triple monoamine reuptake inhibitor that inhibits norepinephrine, serotonin (5-HT), and dopamine reuptake function.1,2 In vivo, tesofensine (2 mg/kg, s.c.) reduces body weight and food intake in a rat model of high-fat diet-induced obesity.1
1.Axel, A., M,D., Mikkelsen, J.D., and Hansen, H.H.Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of α1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese ratNeuropsychopharmacology35(7)1464-1476(2010) 2.van de Giessen, E., de Bruin, K., la Fleur, S.E., et al.Triple monoamine inhibitor tesofensine decreases food intake, body weight, and striatal dopamine D2/D3 receptor availability in diet-induced obese ratsEur. Neuropsychopharmacol.22(4)290-299(2012)