GlpBio

Tertiapin Q (trifluoroacetate salt)

目录号: GC52354纯度: >95.00%同义词: TPN(M13Q), TPNQ
A peptide derivative of tertiapin
Tertiapin Q (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥5,824.00现货
1
500 μg¥3,066.00现货
1
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产品描述 Description

Tertiapin Q is a peptide derivative of the honeybee venom peptide and inhibitor of inwardly rectifying potassium (Kir) channels, tertiapin.1 It inhibits heteromultimeric potassium channels composed of G protein-activated inward rectifier potassium channel 1 (GIRK1) and GIRK4, also known as Kir3.1 and Kir3.4, respectively, as well as the inward-rectifier potassium channel 1 (Kir1.1; Kis = 13.3 and 1.3 nM, respectively).2 Tertiapin Q inhibits voltage-stimulated hyperpolarization and increases action potential duration in mouse dorsal root ganglion neurons in a concentration-dependent manner.3 It inhibits BK-type potassium channels in Xenopus oocytes expressing the human BK channel α subunit (IC50 = 5.8 nM).

1.Jin, W., Klem, A.M., Lewis, J.H., et al.Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-QBiochemistry38(43)14294-14301(1999) 2.Jin, W., and Lu, Z.Synthesis of a stable form of tertiapin: A high-affinity inhibitor for inward-rectifier K+ channelsBiochemistry38(43)14286-14293(1999) 3.Kanjhan, R., Coulson, E.J., Adams, D.J., et al.Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent mannerJ. Pharmacol. Exp. Ther.314(3)1353-1361(2005)

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

同义词
TPN(M13Q), TPNQ
SMILES
O=C([C@H]1NC([C@@H](NC([C@@H](NC([C@@]2([H])N(CCC2)C([C@](NC([C@](NC([C@](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC3=O)CCCCN)=O)CCCCN)=O)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CCCCN)=O)=O)=O)NC([C@@H](NC([C@H](CSSC1)NC([C@H](CC(C)C)NC([C@@H](N)C)=O)=O)=O)CC(N)=O)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)([H])[C@@H](C)CC)=O)([H])[C@@H](C)CC)=O)=O)CC4=CN=CN4)=O)CCC(N)=O)=O)N[C@H]3CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O
分子式
C106H175N35O24S4 ? XCF3COOH
分子量
2452 g/mol
溶解性
Water: soluble
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol