Telazorlimab (GBR-830) is a humanized monoclonal antibody against OX40 costimulatory receptor on activated T cells. Telazorlimab can be used for the research of autoimmune diseases[1].
OX40 抑制在 T 细胞介导的疾病中发挥重要作用，包括特应性皮炎 (AD)[1]。
[1]. Guttman-Yassky E, et, al. GBR 830, an anti-OX40, improves skin gene signatures and clinical scores in patients with atopic dermatitis. J Allergy Clin Immunol. 2019 Aug;144(2):482-493.e7.