Tauro-ω-muricholic acid is a taurine-conjugated form of the secondary bile acid ω-muricholic acid . Hepatic levels of tauro-ω-muricholic acid are decreased in mice following a diet supplemented with cholic, deoxycholic, chenodeoxycholic, or ursodeoxycholic acid and in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD).1,2 Tauro-ω-muricholic acid is the predominant rare bile acid found in the serum of infants with early-onset neonatal sepsis.3
|1. Zhang, Y., and Klaassen, C.D. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J. Lipid Res. 51(11), 3230-3242 (2010).|2. Tang, Y., Zhang, J., Li, J., et al. Turnover of bile acids in liver, serum and caecal content by high-fat diet feeding affects hepatic steatosis in rats. Biochim. Biophys. Acta. Mol. Cell Biol. Lipids 1864(10), 1293-1304 (2019).|3. Z•hrer, E., Meinel, K., Fauler, G., et al. Neonatal sepsis leads to early rise of rare serum bile acid tauro-omega-muricholic acid (TOMCA). Pediatr. Res. 84(1), 66-70 (2018).