GlpBio

Tauro-β-muricholic acid

目录号: GC72082纯度: >99.00%同义词: TβMCA

Tauro-β-muricholic acid (TβMCA) 是一种三羟基化胆汁酸。Tauro-β-muricholic acid 是一种竞争性、可逆的 FXR 拮抗剂 (IC50 = 40 μM)。Tauro-β-muricholic Acid 具有抗细胞凋亡作用。Tauro-β-muricholic acid 通过维持线粒体膜电位抑制胆汁酸诱导的肝细胞凋亡 (apoptosis)。

Tauro-β-muricholic acid
Cas No.: 25696-60-0
规格价格库存数量操作
1mg¥1,944.00现货
1
5mg¥5,400.00现货
1
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文献被引

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产品描述 Description

Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC50 = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential[1][2].

References:

[1]. Denk GU, et al. Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential. Biochem Biophys Res Commun. 2012 Aug 10;424(4):758-64.

[2]. Sayin SI, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013 Feb 5;17(2):225-35. 

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
25696-60-0
同义词
TβMCA
分子式
C26H45NO7S
分子量
515.70 g/mol
溶解性
DMSO: 25 mg/mL (48.48 mM)
保存条件
-20°C, sealed storage, away from moisture
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol