Tat-NTS Peptide (trifluoroacetate salt)

Tat-NTS peptide is a cell-penetrating peptide composed of the HIV-1 Tat protein transduction domain linked to a 10-amino acid peptide corresponding to residues 228-237 of the repeat III domain of annexin A1, which functions as a nuclear translocation signal (NTS).¹ It blocks the protein-protein interaction between annexin A1 and importin β, preventing nuclear translocation of annexin A1 in primary mouse hippocampal neurons.¹ Tat-NTS inhibits glucose-oxygen deprivation and reperfusion-induced apoptosis in primary mouse hippocampal neurons. In vivo, Tat-NTS (10 mg/kg) reduces infarct size and neuronal apoptosis, as well as decreases the time to reach the platform in the Morris water maze test in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).