TAT-HA2 Fusion Peptide is a bifunctional peptide composed of HIV TAT transmembrane peptide and influenza virus HA2 fusion peptide [1]. TAT-HA2 Fusion Peptide is mainly used to promote the entry of macromolecular drugs into cells and their release from endosomes [2-3].
References:
[1]. Untener EA, Comfort KK, Maurer EI, et al. Tannic acid coated gold nanorods demonstrate a distinctive form of endosomal uptake and unique distribution within cells. ACS Applied Materials & Interfaces. 2013 Sep 11; 5(17): 8366-8373.
[2]. Tünnemann G, Martin RM, Haupt S, et al. Cargo‐dependent mode of uptake and bioavailability of TAT‐containing proteins and peptides in living cells. The FASEB journal. 2006 Sep; 20(11): 1775-1784.
[3]. Morris DP, Snipes LC, Hill SA, et al. A reversible cell penetrating peptide-cargo linkage allows dissection of cell penetrating peptide-and cargo-dependent effects on internalization and identifies new functionalities of putative endolytic peptides. Frontiers in Pharmacology. 2022 Nov 21; 13: 1070464.
TAT-HA2 Fusion Peptide是由HIV TAT跨膜肽和流感病毒HA2融合肽组成的双功能肽 [1]。TAT-HA2 Fusion Peptide主要用于促进大分子药物进入细胞并从内体释放 [2-3]。