GlpBio

Taspoglutide (acetate)

目录号: GC92118纯度: >98.00%同义词: [Aib<sup>8,35</sup>]hGLP-1(7-36)NH<sub>2</sub>; BIM-51077C
Taspoglutide (acetate)是胰高血糖素样肽1受体的激动剂（GLP-1R；人受体Ki=1.1nM）。
Taspoglutide (acetate)
Cas No.: 1022150-16-8
规格价格库存数量操作
1 mg¥350.00现货
1
5 mg¥1,316.00现货
1
10 mg¥2,100.00现货
1
25 mg¥4,816.00现货
1
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产品描述 Description

Taspoglutide is an agonist of the glucagon-like peptide 1 receptor (GLP-1R; Ki = 1.1 nM for the human receptor).1 It induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM). Taspoglutide (1 mg/animal per week) decreases blood levels of glucose and increases blood levels of insulin in an oral glucose tolerance test in Zucker diabetic obese rats. It reduces blood levels of gastric inhibitory polypeptide (GIP), plasma levels of triglycerides, and body weight in the same model.2

References:
[1]. Dong, J.Z., Shen, Y., Zhang, J., et al.Discovery and characterization of taspoglutide, a novel analogue of human glucagon-like peptide-1, engineered for sustained therapeutic activity in type 2 diabetesDiabetes Obes. Metab.13(1)19-25(2011).
[2]. Sebokova, E., Bénardeau, A., Sprecher, U., et al.Taspoglutide, a novel human once-weekly analogue of glucagon-like peptide-1, improves glucose homeostasis and body weight in the Zucker diabetic fatty ratDiabetes Obes. Metab.12(8)674-682(2010).

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1022150-16-8
同义词
[Aib<sup>8,35</sup>]hGLP-1(7-36)NH<sub>2</sub>; BIM-51077C
化学名
8-(2-methylalanine)-35-(2-methylalanine)-36-L-argininamide-7-36-glucagon-like peptide I (human), acetate
SMILES
N=C(N)NCCC[C@@H](C(N)=O)NC(C(C)(C)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC(CNC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@H](O)C)NC(CNC([C@H](CCC(O)=O)NC(C(C)(C)NC([C@@H](N)CC1=CN=CN1)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O.CC(O)=O
分子式
C152H232N40O45 ? XC2H4O2
分子量
3339.7 g/mol
溶解性
PBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
保存条件
-20&#176;C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol