T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity[1].
T01-1 (0-50 nM; 3 days) anti-proliferative activity in HCC1806 cells[1].
Cell Proliferation Assay[1]
| Cell Line: | HCC1806 cells |
| Concentration: | 0-50 nM |
| Incubation Time: | 3 days |
| Result: | Inhibited cell proliferation with an EC50 value of 6.7 nM. |
T01-1 (1 mg/kg; i.v.; single) shows T1/2 values of 2.78 and 1.97 h in female and male rats, respectively[1].
| Animal Model: | Sprague Dawley rat (half male and half female)[1]. | ||||||||||||||||||||
| Dosage: | 1 mg/kg | ||||||||||||||||||||
| Administration: | Intravenous injection; single | ||||||||||||||||||||
| Result: | Pharmacokinetic Parameters of T01-1 in Sprague Dawley rat [1].
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[1]. Li Deliang, et al. Camptothecin derivative and water-soluble prodrug, pharmaceutical composition preparation method, and application. Patent WO2020156189A1.