Sulfo-SPDP-C6-NHS sodium is a sodium salt form of a cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs). SPDP-C6-Sulfo-NHS Ester is a water-soluble, heterobifunctional crosslinker with a Sulfo-NHS ester for amine coupling and a pyridyldithiol group for thiol reactivity. Its C6 spacer enhances flexibility, making it ideal for protein conjugation, ADC development, and surface modification[1].
References:
[1] Beck A, Goetsch L, Dumontet C, Corvaïa N. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
Sulfo-SPDP-C6-NHS sodium是一种可切割ADC连接物的钠盐形式，用于合成抗体-药物偶联物（ADC）。Sulfo-SPDP-C6-NHS sodium是一种水溶性的杂双功能交联剂，具有胺偶联的磺酰- nhs酯和硫醇反应活性的吡啶二硫基。其C6间隔层增强了灵活性，使其成为蛋白质偶联，ADC开发和表面修饰的理想选择[1]。