Sulfaclozine is a sulfonamide antibiotic with antiprotozoal activity.1,2 Dietary administration of sulfaclozine reduces cecal lesion score and oocyst production in a chick model of E. tenella infection in a dose-dependent manner.1 It increases average survival time in a mouse model of T. gondii infection when administered at a dose of 250 mg/kg per day.2 Sulfaclozine has been found in chicken muscle samples from domestic markets and as an environmental contaminant in fish pond water, biogas digester water, and lagoon wastewater from pig farms.3,4 Formulations containing sulfaclozine have been used in the treatment of coccidiosis in poultry.
1.Matsuzawa, T., and Kitano, N.Studies on the mode of action of sulfachloropyrazine against coccidia in chickensJapan Poultry Sci.11(3)75-85(1974) 2.Zeng, Y.-B., Zhu, S.-H., Dong, H., et al.Great efficacy of sulfachloropyrazine-sodium against acute murine toxoplasmosisAsian Pac. J. Trop. Biomed.2(1)70-75(2012) 3.Cao, G., Zhan, J., Shi, X., et al.Analysis of 140 veterinary drugs and other contaminants in poultry muscle by ultrahigh-performance liquid chromatography–tandem mass spectrometryChromatographia81707-718(2018) 4.Hu, F.-Y., He, L.-M., Yang, J.-W., et al.Determination of 26 veterinary antibiotics residues in water matrices by lyophilization in combination with LC-MS/MSJ. Chromatogr. B949-95079-86(2014)