SU 0268 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1; IC50 = 0.059 ?M).1 It is selective for OGG1 over the DNA repair enzymes MTH1, dUTPase, NUDT16, ABH2, ABH3, and SMUG1 at 20 ?M. SU 0268 (0.5 ?M) inhibits OGG1 and increases the number of 8-oxoguanine DNA lesions in HeLa cell lysates.
1.Tahara, Y.-K., Auld, D., Ji, D., et al.Potent and selective inhibitors of 8-oxoguanine DNA glycosylaseJ. Am. Chem. Soc.140(6)2105-2114(2018)