Strigolactone is a type of terpene lactone hormone that regulates various characteristics and overall development of plant roots[1]. Strigolactone has been used to develop the Strigolactone analogues, such as GR24, following GR24 treatment for 48 hours, for MDA-MB-436 cells, the IC50 value was 17.2μmol/L, and for MDA-MB-231 and MCF-7 cells, the IC50 value was 18.8μmol/L[2]. Strigolactone has been used in plant development analysis and research on stress response characteristics, as well as in the development of new derivatives as a model molecule[3-4].
References:
[1] Alvi A F, Sehar Z, Fatma M, et al. Strigolactone: an emerging growth regulator for developing resilience in plants[J]. Plants, 2022, 11(19): 2604.
[2] Pyrzanowska-Banasiak A, Boyunegmez Tumer T, Bukowska B, et al. A multifaceted assessment of strigolactone GR24 and its derivatives: from anticancer and antidiabetic activities to antioxidant capacity and beyond[J]. Frontiers in Molecular Biosciences, 2023, 10: 1242935.
[3] Mashiguchi K, Seto Y, Yamaguchi S. Strigolactone biosynthesis, transport and perception[J]. The Plant Journal, 2021, 105(2): 335-350.
[4] Brewer P B, Koltai H, Beveridge C A. Diverse roles of strigolactones in plant development[J]. Molecular plant, 2013, 6(1): 18-28.
Strigolactone是一种萜烯内酯类植物激素，能够调控植物根系的多种特性及其整体发育[1]。基于Strigolactone开发的Strigolactone类似物GR24在48小时处理后，对MDA-MB-436细胞的IC50值为17.2μmol/L，而对MDA-MB-231和MCF-7细胞的IC50值则为18.8μmol/L[2]。Strigolactone不仅被应用于植物发育分析和胁迫响应特性研究，还作为模型分子用于新型衍生物的研发[3-4]。