Stobadine is a pyridoindole antioxidant.1 It scavenges hydroxyl, peroxyl, and alkoxyl radicals and quenches singlet oxygen in cell-free assays. Ex vivo, stobadine (2 mg/kg) reduces lipid peroxidation induced by hypoxia and reoxygenation in rat forebrain.2 It improves survival in a rat model of carotid artery ligation-induced cerebral ischemia. Stobadine (1 mg/kg, i.v.) increases myocardial blood flow and decreases infarct area in a dog model of myocardial infarction induced by acute occlusion of the left coronary artery.1 Dietary administration of stobadine (0.05% w/w) delays the development of cataracts and reduces eye lens protein oxidation and plasma levels of malondialdehyde (MDA) in a rat model of diabetes induced by streptozotocin .3
1.HorÁkovÁ, L., and štolc, S.Antioxidant and pharmacodynamic effects of pyridoindole stobadineGen. Pharmacol.30(5)627-638(1998) 2.štolc, S., VlkolinskÝ, R., and PavlÁsek, J.Neuroprotection by the pyridoindole stobadine: A minireviewBrain Res. Bull.42(5)335-340(1997) 3.Kyselova, Z., Gajdosik, A., Gajdosikova, A., et al.Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: Comparison with vitamin E and BHTMol. Vis.1156-65(2005)