Stearic acid glycidyl ester-d5 is intended for use as an internal standard for the quantification of stearic acid glycidyl ester by GC- or LC-MS. Stearic acid glycidyl ester is an esterized form of stearic acid containing a glycidyl group. It induces the formation of subcutaneous sarcomas and pulmonary tumors in mice when administered at a doses of 0.005-10 mg/animal and induces the formation of breast carcinomas at 0.1 mg/animal.1 However, serum levels of stearic acid glycidyl ester are decreased in patients with prostate cancer compared to patients with benign prostatic hyperplasia and are negatively correlated with total cholesterol, LDL, and apolipoprotein B (ApoB) levels.2
1.Swern, D., Wieder, R., McDonough, M., et al.Investigation of fatty acids and derivatives for carcinogenic activityCancer Res.30(4)1037-1046(1970) 2.Xu, B., Chen, Y., Chen, X., et al.Metabolomics profiling discriminates prostate cancer from benign prostatic hyperplasia within the prostate-specific antigen gray zoneFront. Oncol.11730638(2021)