Statine ((3S,4S)-Statine) is a gamma amino acid that occurs twice in the sequence of pepstatin[1]. Statine ((3S,4S)-Statine) mimics the tetrahedral transition state of pepsin and other acidic proteases[1]. Pepstatin is a protease inhibitor active against pepsin and other acidic proteases[2]. Pepstatin is a potent acetylase inhibitor that is a hexapeptide containing the unusual amino acid Statine ((3S,4S)-Statine) with the sequence Iva-Val-Val-Sta-Ala-Sta[3].
References:
[1]Marciniszyn Jr J, Hartsuck J A, Tang J. Mode of inhibition of acid proteases by pepstatin[J]. Journal of Biological Chemistry, 1976, 251(22): 7088-7094.
[2]Kunimoto S, AOYAGI T, NISHIZAWA R, et al. Mechanism of inhibition of pepsin by pepstatin. II[J]. The Journal of Antibiotics, 1974, 27(6): 413-418.
[3]Guegan R, Diaz J, Cazaubon C, et al. Pepstatin analogs as novel renin inhibitors[J]. Journal of medicinal chemistry, 1986, 29(7): 1152-1159.
Statine ((3S,4S)-Statine)是一种γ氨基酸，在胃蛋白酶抑制剂的序列中出现两次[1]。Statine ((3S,4S)-Statine)模拟胃蛋白酶和其他酸性蛋白酶催化的四面体过渡态[1]。胃蛋白酶抑制剂是一种对胃蛋白酶和其他酸性蛋白酶有活性的蛋白酶抑制剂[2]。胃蛋白酶抑制素是一种有效的乙酰蛋白酶抑制剂，它是一种六肽，含有不常见的氨基酸他汀（Statine ((3S,4S)-Statine)），具有Iva-Val-Val-Sta-Ala-Sta序列[3]。