GlpBio

ST-1006

目录号: GC70497纯度: >99.00%
ST-1006是一种强效组胺H4受体激动剂，pKi值为7.94。
ST-1006
Cas No.: 1196994-11-2
规格价格库存数量操作
1 mg¥1,755.00现货
1
5 mg¥4,320.00现货
1
10 mg¥6,912.00现货
1
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产品描述 Description

ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect.

ST-1006 (10 μM) is a potent inducer of basophil migration and induces migration of basophils[2].
ST-1006 (0-100 μM) suppresses FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils[2].

ST-1006 (1-100 mg/kg; s.c.; Male CD-1 mice) has anti-inflammatory effect and displays an antipruritic effect[1].

References:
[1]. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397.
[2]. Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
1196994-11-2
分子式
C16H20Cl2N6
分子量
367.28 g/mol
溶解性
DMSO : 125 mg/mL (340.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
保存条件
4°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol