SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1].
SOD1-Derlin-1 inhibitor-2 (compound 56-59; 0.1-100 μM) 以剂量依赖性方式抑制 SOD1-Derlin-1 相互作用[1]。
SOD1-Derlin-1 inhibitor-2 (compound 56-59; i.c.v.; 3 mM, 流速 0.15 μL/h) 改善 ALS 模型小鼠的 ALS 病理[1]。
| Animal Model: | ALS model C57BL/6 mice[1] |
| Dosage: | 3 mM, flow rate 0.15 μL/h |
| Administration: | intracerebroventrical injection |
| Result: | Had significantly delayed onset, by a median of 4.5 weeks (14.5% improvement) and prolonged survival, by a median of 5 weeks (14.2% improvement). |
[1]. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668.