SIK-IN-1

SIK-IN-1 (Compound 53) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC₅₀s of 0.1, 0.4 and 1.5 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC₅₀ of 0.5 nM, stimulates the LPS -induced IL-10 release with EC₅₀ of 4 nM in human macrophages^[1].

References:
[1]. Bootsma AN et al., Heterocyclic sik inhibitors. WO2024062360A1.