Selcopintide (Cpne7-DP) acetate consists of a synthetic peptide corresponding to the 10 amino acid residue 344-353 fragment of the hCPNE7 protein. Selcopintide acetate highly reproduces the in vitro effects of CPNE7 by upregulating odontoblast marker genes, DSPP, and Nestin. Selcopintide acetate promotes dentin regeneration in dentinal defects of various degrees and that the regenerated hard tissue demonstrates the characteristics of true dentin[1].
Selcopintide (Cpne7-DP) acetate 直接穿透成牙本质细胞 (MDPC-23 细胞)[1]。
Selcopintide (1, 10 μg) acetate 以剂量依赖性方式增加 dspp 启动子活性[1]。
Selcopintide (Cpne7-DP; 10 µg 在 0.5% 纤维蛋白凝胶中与人 DPC 细胞混合后皮下移植) acetate 在浅腔和深腔模型中促进牙本质样组织形成和管状牙本质和牙本质小管闭塞的再生[1]。
| Animal Model: | Immunocompromised mice (NIH-bg-nu-xid)[1] |
| Dosage: | 10 µg |
| Administration: | Subcutaneous transplantation in a 0.5% fibrin gel |
| Result: | Promotes dentin-like tissue formation. Promotes the regeneration of tubular dentin and dentinal tubule occlusion in shallow and deep cavity models. |
[1]. Lee YS, et al. Tubular Dentin Regeneration Using a CPNE7-Derived Functional Peptide. Materials (Basel). 2020;13(20):4618. Published 2020 Oct 16.